LA PAZ , (See Map) is in a valley high in the Andies. It has a median temperature of about 35-65 degrees year round. It is either very dry and dusty and windy, or very wet and muddy and windy. The summer months (November and December) see highs in the 60's. Still the nights are very cold and heaters are not used (and sometimes not available) at night.
La Paz is the capital of and is located at the unlikely altitude of 12,500 feet, its airport is appropriately called El Alto meaning "the high" at over 14,000 feet.La Paz is below the airport. The road corkscrews into an immense bowl like canyon. It's a big city of but dwarfed by its setting at the foot of Nevado Illimani.
The traveler will see the tremendous differences in the people and buildings that are a result of 's economy, the poorest in South America. From adobe huts to glass skyscrapers, it is a contrast that leaves a profound impression on the traveler.
Actually founded in 1548 as the "city of peace" its history was punctuated by various revolutions and wars and in the 1809 gained independence from Spain. 
La Plaza de los Españoles, that today is the Plaza Murillo, is the location for government buildings and the main cathedral.
Today La Paz is a vibrant city, growing and expanding in all directions. with a population of more than a 1,500,000million. 
Climate
Within La Paz there are different climates according to each zone's altitude. The average temperature in winter is 59F and 72F in summer. In the summer, rain falls on most afternoons. In the winter, days are slightly cooler, but the sky is mostly clear and sunny.
Taxis are plentiful and not expensive although some are of dubious ancestry. The city of La Paz is best "walked" to appreciate the changes that have occurred in the establishment of the city. There have been, historically, three 'city centers' and the influence of each, helps you appreciate what we see today. Again a guide makes these areas come alive. A word of caution. The extreme altitude dictates flatlanders take it easy especially for the first few days. You may want to take along some medication to help you cope.
Main Attractions
Presidential Palace: Also known as the Palacio Quemado (Burnt Palace) due to repeating fire episodes the building endured in the past. 
The Cathedral: Built in 1835, the cathedral is an impressive building worth seeing. It is located in the Plaza Murillo next to the Presidential Palace. 
Mercado de Brujas (Witches' Market): Merchandise sold here includes herbs, remedies as well as other ingredients used in Aymara traditions. 
Tiahuanaco: This ruins, built over 1,000 years ago by the Tiahuancu people, are one of the most exciting places to visit.
Some details
Now La Paz is a relatively safe city but like all big cities the traveler should be prudent in the areas visited and display of jewelry or cash.
The electric currency is, as in most of South America, 220 volts most better hotels have converters you can borrow or rent.
The currency is the no which exchanges for the USD at about 7 to one although as in the rest of the world, bank money machines are pretty easy to find.
Spanish is of course the main language and except for the more upscale commercial areas and hotels English is not often found.
 

ORURO (See map) was founded on November 1st, 1606. During the 17th century, Oruro became the largest city in the Alto Peru region. After becoming a ghost town in the early 19th centruy it has grown to almost 200,000 inhabitants.
Oruro lies north of the salty lakes Uru-Uru and Poopó (no kidding poo poo) and it is just three hours (by bus) south from La Paz. It is at an altitude of 12,000 feet above sea level, Oruro its well known for its cold weather. Warmer temperatures generally take place during August, September and October, after the worst of the winter chills and before the summer rains. From May to early July, night time temperatures combined with cool wind can bring the temperature down to about -40 C. 
Tourist Attractions:
 Carnival Festivities: Annual celebration consisting of brightly custom-dressed dancers performing a wide variety of dances depicting archangels, devils, Incas, Spanish conquistadors etc. The festivities begin the first Saturday before Ash Wednesday. Also know as the Diablada. 
 The Museo Mineralógico: (Mining Museum) Exhibits of precious stones, minerals, and fossils.
 

POTOSI,(See map), Potosi was founded by the discovery of ore in silver-rich Cerro Rico (rich hill) in 1544. Large-scale mining began immediately and the first of the silver was sent to Spain. In 1672, a mint was established to coin silver and water reservoirs were built to fulfill the growing population's needs. Then more than eighty six churches were built and the city's population increased to nearly 200,000, making it one of the largest and wealthiest city in Latin America and in the world. In 1987 (in Paris, France), the UNESCO declared the city of Potosí a "World Heritage Site" in recognition for its rich history and its wealth of colonial architecture. Its current population is close to 125,000.
Potosí is at an altitude of 13,300 feet making it the highest city in the world. The city is well-known for its cool weather and sometimes freezing rain. Because of the altitude travelers are cautioned to take it easy at least for a few days.
Note that currently there is no airservice to Potosi.
Tourist Attractions
 Cerro Rico: Mine tours are available. 
 La Casa de la Moneda: The first mint in Potosí, was built during the second half of the 18th century to control minting activities right where the silver was extracted. The Museo de la Casa de la Moneda has exhibits on silver and gold coining as well as colonial paintings. 
 

SANTA CRUZ  de la Sierra, (See map), was founded in 1560. Presently it boasts the second largest population in Bolivia with almost 1,000,000, it is located 50 km east of the Cordillera Oriental foothills.
Its recent growth is due to the connection through roads and highways with other major centers and the completion of the railway line to Brazil in the mid-1950s which opened trade routes to the east. Tropical agriculture (sugar, rice, cotton, and soybean plantations) prospered and the city entered a period of expansion and economic growth that continues to the present day. The city is connected by railways with Brazil and Argentina, and by road with Cochabamba, the Chaco, and Trinidad.
Santa Cruz has an altitude of 1,500 feet above sea level. Santa Cruz has a sunny and semi-tropical weather, with an average temperature of 70F in winter and as high as 90F in summer months. During winter, rainfall occurs in short downpours, but on summer a single deluge can last for days. Santa Cruz also experiences heavy and chilly winds called surazos that blow in from the Argentine pampas.
Tourist attractions:The Piraí Rive are ideal for weekend picnics, Its Municipal Zoo is one of the best zoos in South America, features birds, reptiles, mammals, from the region as well as endangered and exotic species.  Plaza 24 de Septiembre is ideal for relaxing and watching sloths hanging in the tall trees. Its cathedral dates back to the early 1600's. The cathedral museum displays religious art work, gold and silver artifact from the Jesuit missions. Parque Nacional Noel Kempff Mercado: Really worth seeing, this spectacular natural park, about 440 Km northeast of Santa Cruz, has an incredible scenery of waterfalls, rivers, rainforests and a wide variety of flora and fauna (alligators, pink dolphins, caimans, river otters, tapirs, spider monkeys, etc.)
 

SUCRE, (See map)(currently 170,000 inhabitants) was originally founded as the city of La Plata in 1538. Its foundation was a result of mining activities overseen by Gonzalo Pizarro, of Peru fame. During the 17th century, La Plata was the legal, religious, and cultural center of the area. It was here that the first cry of Independence in the Americas was heard in 1809. In 1825 independence was declared and the Republic of Bolivia ewas created named after the liberator Simón Bolivar. The name of the city was changed from La Plata to Sucre in honor of Mariscal Antonio José de Sucre, who fought along with Bolivar. UNESCO declared the Historic City of Sucre a "World Heritage Site" in recognition for its rich history and its wealth of colonial architecture.
The city of Sucre is located an an altitude of 9,000 feet above sea level. The weather is mild and pleasant averaging 68F.
Tourist attraction:
 Casa de la Libertad: House located on the main plaza, where the declaration of 
independence of Bolivia was signed on august 6th, 1825. Portraits of presidents, military
decorations, and documents are displayed. Museo de la Recoleta: Established by the Franciscan Order in the early 16th century, this placed served as a convent, barracks, prison, and museum.  Museo del Arte Moderno: Displays works of modern Bolivian painting and sculptures. Museo Antropológico: Displays skulls, pottery, mummies, and textiles from the eastern tribes of Bolivia.  Dinosaur Marks : Located 10 Km, north of the city of Sucre there are dinosaur footprints and prehistoric plant and animal fossils. We bet you did not know South America had Dinosaurs!

TARIJA,(See map), was founded on July 4th, 1574 as Villa de San Bernardo de Tarija.Tarija chose to become part of Bolivia which won its independence and formally established as a Republic in 1825. Currently the city of Tarija had a population of 130,000 inhabitants.
Tarija is at an altitude of 6,000 meters above sea level. Its weather is mild and pleasant although sometimes winter nights may get slightly cooler. Tarija is well-known for its Mediterranean-like climate and vineyards. 
Tourist attractions:
 Tomatasis a natural bathing resort located 5 Km. from the city of Tarija. Its beaches are bathed by waters from the Guadalquivir and Erquis rivers. There is also an small forest for camping. 
 Rincón de la Victoria: Paradisiacal vegetation spot located at 18 Km from the city. Being one of the main tourist attractions, it offers a close encounter with nature and its wonderful scenic views. Ideal for weekend trips. 
 San Lorenzo: Located at 16 Km from the city of Tarija, this town displays Spanish colonial styles, wood-carved balconies, stone-layered streets. In this town is the house of Eustaquio "Moto" Méndez, hero of Bolivia's fight for independence from the Spanish rule. The house is currently a museum. 
 

TITICACA and COPACABANA, (See map) the cradle of Inca civilization, is the second largest lake of South America (after Maracaibo). It is reputed to be the highest navigable lake in the world (about 12,500 ft. above sea level), extending from southeastern to western Bolivia. The lake is 122 miles long with an average width of 35 mi. The lake has waves, testament to its size and not surprisingly the waters are cold and deep, over 1,200 feet. At that altitude and fed from snow-clad Andes the lake does not invite swimming. It is the remnant of an ancient inland sea and the blue waters make a beautiful contrast to the parched altiplano. Lake Titicaca is the world's highest lake navigable to large vessels.
  The Totora reeds that grow on the banks of Lake Titicaca have been used for building ships by inhabitants of this region for centuries. After failing in attempts to cross the South Pacific, Thor Hyerdahl came to Lake Titicaca to hire the expert reed boat builders native to this area. After cutting the reeds, they're dried in the sun for about two weeks, then intricately woven to build their boats.
Copacabana Bolivia is the site of the Festival of the Virgin of Copacabana, it is located on the shores of Titicaca lake and attracts hundreds of pilgrims each year for the Virgin's festivities.Normally is is a sleepy fishing village but during this festival(August) it comes alive with the sounds and colors that will give the traveler memories to last a lifetime.
 

TRINIDAD,(See map), (La Santísima Trinidad, the Most Holy Trinity) was founded in 1686 by Padre Cipriano Barace on the Mamoré river In 1769, disease and floods caused the city to be relocated on the shores of Arroyo de San Juan. Trinidad is the capital city of the department of Beni. Trinidad has about 78,000 people.Trinidad has a tropical and humid climate, as you would expect for a city near the equator that is close to sea level it is hot all year-round ( from 75F to 85F). The heaviest rains are in the summer. 
How to Get There From any main city in Bolivia via: LAB, AEROSUR, and TAM. 
Tourist attractions:
Santuario Chuchini there are prehistoric earthworks thought to be constructed by the Paititi indians over 5,000 years ago. Laguna Suárez isa large artificial lake located about 2 miles from Trinidad. At Puerto Barador, along the shores of the Mamoré river, pink river dolphins are a delight to tourists.